Erratum to: Metastatic Merkel cell carcinoma response to nivolumab
نویسندگان
چکیده
[This corrects the article DOI: 10.1186/s40425-016-0186-1.].
منابع مشابه
Metastatic Merkel cell carcinoma response to nivolumab
BACKGROUND Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy with limited treatment options. Several lines of evidence support the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis as a likely contributor to immune evasion in MCC. CASE PRESENTATION We report a case of a patient with metastatic MCC with a significant and durable response to nivolumab...
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Metastatic Merkel cell carcinoma (MCC) is a lethal, Merkel cell polyomavirus (MCPyV) cancer with no currently available effective therapy. Harnessing the immune system through an immune checkpoint blockade is an attractive option because the immune system appears to be dysfunctional in the Merkel cell tumor microenvironment. Although MCPyV is expressed in 80% of MCCs and serves as a powerful an...
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Extrapulmonary small-cell neuroendocrine cancers are rare in clinical practice. They are frequently metastatic at the time of diagnosis with survival in months even with the most intensive treatment. So far, treatment recommendations for this group rely on data from the similar but more common small-cell carcinoma of the lungs. Immune checkpoint inhibitors are being investigated for the treatme...
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Dispersed neuroendocrine system (D.N.S) consists of a wide variety of cells that are present in the central and peripheral nervous system and in many classic endocrine organs and different tissues such as respiratory and gastrointestinal tracts, skin, prostate, breast and also their neoplasm show neuroendocrine differentiation by electron microscopy, immunohistochemistry or biochemical techniqu...
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Nivolumab is a fully human immunoglobulin-G4 monoclonal antibody that selectively binds to the programmed death-1 (PD-1) membrane receptor, blocking the interaction of PD-1 with its 2 known ligands, PD-L1 and PD-L2.1 Blockade of PD-1 is believed to promote antitumor immune responses by preventing downregulation of T-cell activation and proliferation within the tumor microenvironment.1 Nivolumab...
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2017